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髓过氧化物酶抗中性粒细胞胞质IgG抗体
品名：
髓过氧化物酶抗中性粒细胞胞质IgG抗体
货号：
规格：
 
品牌：
国产
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快速询价
英文名称 Myeloperoxidase
中文名称 髓过氧化物酶抗中性粒细胞胞质IgG抗体
别    名 Myeloperoxidase; MPO; c-ANCA; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN.
规格价格 0.1ml/600元 购买    0.2ml/1000元 购买    
研究领域 肿瘤  细胞生物  免疫学  激酶和磷酸酶  淋巴细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 77kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Myeloperoxidase
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
生 产 商 BIOSS
PubMed PubMed
产品介绍 background:
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008].

Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Subunit:
Tetramer of two light chains and two heavy chains.

Subcellular Location:
Lysosome.

DISEASE:
Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.

Similarity:
Belongs to the peroxidase family. XPO subfamily.

Gene ID:
4353

Database links:

Entrez Gene: 4353 Human

Entrez Gene: 17523 Mouse

Entrez Gene: 303413 Rat

Omim: 606989 Human

SwissProt: P05164 Human

SwissProt: P11247 Mouse

Unigene: 458272 Human

Unigene: 4668 Mouse

Unigene: 47782 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

髓过氧化物酶MPO,作为一种白细胞酶,具有介导炎性反应、调节免疫应答等多种功能,并可参与疾病的发生发展过程。同时,髓过氧化物酶基因存在基因多态性,也影响机体对疾病的易感性. 在正常淋巴组织中和各种髓样细胞增生症中，MPO均有较强表达，如：淋巴样细胞、原核细胞、肥大细胞、浆细胞以及各种上皮源性肿瘤和肉瘤等。
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